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ABOUT MEDCHEM PARTNERS |
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Our Founders
 Tsvetelina
Lazarova,
Ph.D. – Co-Founder
Dr. Lazarova has over 15 years of
experience in organic chemistry, 10 of those in biotech in the
Boston area. She was involved with 2 start-up
companies. Dr. Lazarova received her B.A. degree in chemistry from
Harvard University, M.A. in organic chemistry from MIT and PhD in
organic
Chemistry from University of
California, Los Angeles. She studied with Profs. Stuart Schreiber,
Stephen Buchwald and Michael E. Jung.
While at Enanta Pharmaceuticals, Dr.
Lazarova initiated the chemistry portion of the
immunology program and advanced two lead series to
pre-clinical
status as potential therapies for asthma and psoriasis.
At Daiichi Asubio Research
Laboratories, Dr. Lazarova led the nuclear hormone receptor project, which relied on
structure guided drug design and rapid
generation of focused libraries to
develop novel cholesterol lowering agents.
Dr. Lazarova has also worked at ARIAD
Pharmaceuticals (where she was the first chemist hired) where she
worked with
peptide mimetics involved in
signal transduction pathways and on natural product analogs as
potential protein transport inhibitors.
At Cubist Pharmaceuticals, Dr. Lazarova
designed and synthesized second generation analogs of Daptomycin (CubicinTM), a novel lipopetide antibiotic
used for the treatment of skin and soft tissue infections.
 Steven Riesinger,
Ph.D. – Co-Founder
Dr. Riesinger has over 15 years’
experience in organic chemistry, 9 of those in the biotech arena
where he has been involved in the start up of three
companies. Dr, Riesinger received his Ph.D. at Emory University in
organic chemistry followed by postdoctoral fellowships at Uppsala
University with Dr. Jan-E Bäckvall and at Montana State University
in the laboratory of Dr. Tom Livinghouse.
During Dr. Riesinger’s tenure at
Shionogi BioResearch he spearheaded the initial set up of the medicinal and combinatorial chemistry laboratories
and
was responsible for managing its lead anti-cancer program.
As a founding scientist at Enanta
Pharmaceuticals, Dr. Riesinger played a lead role in setting up
the company’s research laboratories, establishing the
medicinal chemistry group, and directing its anti-viral programs,
which ultimately produced protease inhibitors active in the
single-digit nanomolar range.
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Our Facility
MedChem Partners has a laboratory in Medford, MA just outside
Boston where we perform state of the art medicinal chemistry,
custom synthesis and scale-up.
Our labs are fully outfitted
with modern glassware and equipment including the latest
Biotage FLASH chromatography system,
300MHz Bruker NMR, and an Agilient/Micromass LC/MS.
We have the capability to perform virtually any
chemistry needed to prepare or modify small molecule
therapeutics of many classes.
We can work on scales from milligrams up to half kilo
scale.
In addition to our internal resources,
we have access to world class NMR and LC/MS
facilities at Harvard, Northeastern, and MIT.
We also have Scifinder, Discoverygate, ACD, and
online access to many important scientific journals.  |
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